Obesity and the brain

According to some important scientific studies major systemic diseases and psychiatric disorders and medications used to treat them can increase the risk of obesity. The systemic diseases that increase the risk of obesity include some rare genetic diseases and some congenital or acquired medical conditions: hypothyroidism, Cushing's disease, lack of growth hormone (GH) (Rosen T, Bosaeus I TolliJ, Lindstedt G, Bengtsson BA, 1993 "Increasing decreased body fat mass and extracellular fluid volume in adults with growth hormone deficiency) and eating disorders: binge eating and night eating syndrome.

Obesity is not a psychiatric condition, but there is evidence that the risk of overweight and obesity in patients with psychiatric disorders is higher than in people without these types of disorders. (ChilesC, PJ Van Wattum. "Psychiatric Aspects of the obesity crisis", 2010 Psychiatric Times).

Some medications can cause weight gain or changes in body composition. These include insulin, sulfonylurea, tiazolinedioni (drugs used to treat diabetes type 2), atypical antipsychotics, antidepressants, steroids, some anticonvulsants, Pizotifen and some types of hormonal contraceptives (Haslam DW, James WP, 2005 "Obesity" Lancet 366)

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